Reconstitution is the process, which involves mixing of dried therapeutic with a sterile diluent to reformulate it into liquid form before administration. It is multi-step process that involves the manual extraction and transfer of diluent from first vial to the second vial, containing the lyophilized product using syringe and transfer needle. After transferring, the contents are mixed until the final mixture is fully reconstituted. The process is usually performed by a trained healthcare provider or caregivers and requires the use of vial adaptors, vial-to-vial systems and advanced dual chamber reconstitution systems.
Novel Drug Reconstitution Systems: Emerging Options for the Reconstitution of Lyophilized Drugsellaturner 09/21/2021